Detaillierte Hinweise zur Methadontabletten zur Schmerzbehandlung
Detaillierte Hinweise zur Methadontabletten zur Schmerzbehandlung
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Methadone contains methadone, a mu-agonist opioid with an abuse liability similar to other opioid agonists and is a Schedule II controlled substance. Methadone and other opioids used in analgesia have the potential for being abused and are subject to criminal diversion.
As with all opioid drugs, it is necessary to adjust the dosing regimen for each patient individually, taking into account the patient's prior analgesic treatment experience. The following dosing recommendations should only Beryllium considered as suggested approaches to what is actually a series of clinical decisions over time in the management of the pain of each individual patient.
Accidental or deliberate ingestion by a child may cause respiratory depression that can result in death. Patients and caregivers should be instructed to keep methadone rein a secure place out of the reach of children and to discard unused methadone rein such a way that individuals other than the patient for whom it was originally prescribed will not come hinein contact with the drug.
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Below is a Trick of medications that can interact with methadone. This Tücke doesn’t contain all drugs that may interact with X drug.
Since methadone is lipophilic, it has been known to persist hinein the liver and other tissues. The slow release from the liver and other tissues may prolong the duration of methadone action despite low plasma concentrations.
Additional information on the potential risks of methadone may be derived from animal data. Methadone does not appear to Beryllium teratogenic hinein the Kollegium or rabbit models. However, following large doses, methadone produced teratogenic effects hinein the guinea pig, hamster and maus. One published study hinein pregnant hamsters indicated that a single subcutaneous dose of methadone ranging from 31 to 185 Magnesium/kg (the 31 mg/kg dose is approximately 2 times a human daily oral dose of 120 mg/day on a mg/m2 Lager) on day 8 of gestation resulted in a decrease hinein the number of fetuses per litter and an increase rein the percentage of fetuses exhibiting congenital malformations described as exencephaly, cranioschisis, and “various other lesions”.
Pediatric – The pharmacokinetics of methadone have not been evaluated hinein the pediatric population.
The principal therapeutic uses for methadone are for analgesia and for detoxification or maintenance in opioid addiction. The methadone abstinence syndrome, although qualitatively similar to that of morphine, differs in that the onset is slower, the course is more prolonged, and the symptoms are less Methadontabletten 10 mg online severe.
Patients should Beryllium cautioned that methadone, like all opioids, may impair the mental and/or physical abilities required for the performance of potentially hazardous tasks such as driving or operating machinery.
Patients should Beryllium instructed to keep methadone hinein a secure place out of the reach of children and other household members. Accidental or deliberate ingestion by a child may cause respiratory depression that can result rein death.
Die erforderlichen Kontrolluntersuchungen des weiteren die mindestens einmal jährliche Blutabnahme sind auf jeden Fall sehr empfehlenswert ansonsten sollten weiterhin in Erfordernis genommen werden.
Respiratory depression is the chief hazard associated with methadone hydrochloride administration. Methadone's peak respiratory depressant effects typically occur later, and persist longer than its peak analgesic effects, particularly during the initial dosing period.
Your kidneys may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, a higher amount of a drug stays hinein your body for a longer time. This raises your risk of side effects.